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N-methylformamide 123-39-7 SAFETY DATA SHEETS

2018.09.14 Category:Company profile Share  

  SAFETY DATA SHEETS

  According to Globally Harmonized System of Classification and Labelling of

  Chemicals (GHS) - Sixth revised edition

  Version: 1.0

  Creation Date: Aug 10, 2017

  Revision Date: Aug 10, 2017

  1.Identification

  1.1 GHS Product identifier

  Product name N-methylformamide

  1.2 Other means of identification

  Product number-

  Other names N-Methylformamid

  1.3 Recommended use of the chemical and restrictions on use

  Identified uses For industry use only. Intermediates

  Uses advised againstno data available

  1.4 Supplier's details

  1.5 Emergency phone number

  Emergency phone number-

  Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

  2.Hazard identification

  2.1 Classification of the substance or mixture

  Acute toxicity - Dermal, Category 4

  Reproductive toxicity, Category 1B

  2.2 GHS label elements, including precautionary statements

  Pictogram(s)

  Signal word Danger

  Hazard statement(s) H312 Harmful in contact with skin

  Precautionary statement(s)

  Prevention

  P280 Wear protective gloves/protective clothing/eye protection/face protection.

  P201 Obtain special instructions before use.

  P202 Do not handle until all safety precautions have been read and understood.

  P302+P352 IF ON SKIN: Wash with plenty of water/...

  P312 Call a POISON CENTER/doctor/…if you feel unwell.

  Response

  P321 Specific treatment (see ... on this label).

  P362+P364 Take off contaminated clothing and wash it before reuse.

  P308+P313 IF exposed or concerned: Get medical advice/ attention.

  Storage P405 Store locked up.

  Disposal P501 Dispose of contents/container to ...

  2.3 Other hazards which do not result in classification

  none

  3.Composition/information on ingredients

  3.1 Substances

  Chemical name Common names and synonyms CAS numberEC numberConcentration

  N-methylformamideN-methylformamide 123-39-7 none 100%

  4.First-aid measures

  4.1 Description of necessary first-aid measures

  General advice

  Consult a physician. Show this safety data sheet to the doctor in attendance.

  If inhaled

  Fresh air, rest. Refer for medical attention.

  In case of skin contact

  Rinse skin with plenty of water or shower.

  In case of eye contact

  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

  If swallowed

  Rinse mouth. Rest. Refer for medical attention .

  4.2 Most important symptoms/effects, acute and delayed

  SYMPTOMS: Symptoms of exposure to this compound include irritation of the mucous membranes and upper respiratory tract. Other symptoms

  include liver damage, eye irritation with discomfort, tearing or blurring of vision, skin irritation with discomfort or rash, abnormalities of liver function

  with jaundice, temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination and loss of

  consciousness. ACUTE/CHRONIC HAZARDS: This compound may be absorbed through the skin and cause skin irritation. It may also irritate

  the eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide

  and nitrogen oxides.

  4.3 Indication of immediate medical attention and special treatment needed, if necessary

  Absorption, Distribution and Excretion

  8 healthy male subjects were exposed to dimethylformamide vapor at a concn of 8.79 + or - 0.33 ppm for 6 hr/day for 5 consecutive days. All

  urine voided by the subjects was collected from the beginning of the first exposure to 24 hr past the end of the last exposure & each sample was

  analyzed for monomethylformamide. Monomethylformamide was rapidly eliminated from the body with urine values peaking within a few hr

  following the end of each exposure period. The mean for the 7 hr (end of exposure) sample was 4.74 ug/ml urine or 736.8 ug.

  5.Fire-fighting measures

  5.1 Extinguishing media

  Suitable extinguishing media

  Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

  5.2 Specific hazards arising from the chemical

  This chemical is combustible.

  5.3 Special protective actions for fire-fighters

  Wear self-contained breathing apparatus for firefighting if necessary.

  6.Accidental release measures

  6.1 Personal precautions, protective equipment and emergency procedures

  Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel

  to safe areas. Avoid breathing dust. For personal protection see section 8.

  6.2 Environmental precautions

  Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers.

  6.3 Methods and materials for containment and cleaning up

  Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  7.Handling and storage

  7.1 Precautions for safe handling

  Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide

  appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

  7.2 Conditions for safe storage, including any incompatibilities

  Separated from oxidants.

  8.Exposure controls/personal protection

  8.1 Control parameters

  Occupational Exposure limit values

  no data available

  Biological limit values

  no data available

  8.2 Appropriate engineering controls

  Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

  8.3 Individual protection measures, such as personal protective equipment (PPE)

  Eye/face protection

  Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government

  standards such as NIOSH (US) or EN 166(EU).

  Skin protection

  Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous

  substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without

  touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable

  laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive

  89/686/EEC and the standard EN 374 derived from it.

  Respiratory protection

  Wear dust mask when handling large quantities.

  Thermal hazards

  no data available

  9.Physical and chemical properties

  Physical state clear, colorless liquid.

  Colour no data available

  Odour no data available

  Melting point/ freezing point -5°C(lit.)

  Boiling point or initial boiling point and boiling range 183°C(lit.)

  Flammability Combustible.

  Lower and upper explosion limit / flammability limit no data available

  Flash point 98°C(lit.)

  Auto-ignition temperature 322.78°C

  Decomposition temperature no data available

  pH no data available

  Kinematic viscosity 1.99 mN/s/m @ 15°C; 1.65 mN/s/m @ 25°C

  Solubility In water:miscible

  Partition coefficient n-octanol/water (log value) log Kow = -0.97

  Vapour pressure 0.808mmHg at 25°C

  Density and/or relative density 1.011

  Relative vapour density (air = 1): 2.04

  Particle characteristics no data available

  10.Stability and reactivity

  10.1 Reactivity

  no data available

  10.2 Chemical stability

  Solution: A 25% aqueous solution is stable at room temperature for at least one week (NMR).

  10.3 Possibility of hazardous reactions

  A very dangerous fire hazard when exposed to heat or flame.N-METHYLFORMAMIDE is incompatible with benzene sulfonyl chloride. It is also

  incompatible with strong oxidizing agents, acids, bases and acid chlorides. It may react with chlorine, bromine, nitrates, nitric acid, triethylaluminum,

  potassium permanganate, chromic acid, chromic anhydride, chromium trioxide, borohydrides, hydrides, thionyl chloride, metallic sodium,

  phosphorus trioxide, diborane, (octafluoroisobutyrate + sodium nitrite) and (perchloryl fluoride + potassium methyl 4,4-dinitrobutyrate).

  10.4 Conditions to avoid

  no data available

  10.5 Incompatible materials

  VIOLENT REACTION WITH BENZENE SULFONYL CHLORIDE.

  10.6 Hazardous decomposition products

  When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

  11.Toxicological information

  Acute toxicity

  Oral: LD50 BALB/C Mouse oral 2.6 g/kg

  Inhalation: no data available

  Dermal: no data available

  Skin corrosion/irritation

  no data available

  Serious eye damage/irritation

  no data available

  Respiratory or skin sensitization

  no data available

  Germ cell mutagenicity

  no data available

  Carcinogenicity

  no data available

  Reproductive toxicity

  no data available

  STOT-single exposure

  no data available

  STOT-repeated exposure

  no data available

  Aspiration hazard

  no data available

  12.Ecological information

  12.1 Toxicity

  Toxicity to fish: no data available

  Toxicity to daphnia and other aquatic invertebrates: no data available

  Toxicity to algae: no data available

  Toxicity to microorganisms: no data available

  12.2 Persistence and degradability

  AEROBIC: N-Methylformamide, present at 400 mg/l, reached 4%, 98%, and 100% of its theoretical BOD in 3 hrs, 3 days, and 7 days,

  respectively, using an industrial activated sludge inoculum and the Zahn-Wellens test(1). Using the BOD test, N-methylformamide achieved 2% of

  its theoretical BOD after 5 days(1). N-Methylformamide has also been shown to biodegrade by microorgansism obtained through soil

  enrichment(2). Therefore, N-methylformamide may biodegrade in the environment(SRC).

  12.3 Bioaccumulative potential

  An estimated BCF of 3 was calculated for N-methylformamide(SRC), using a log Kow of -0.97(1) and a regression-derived equation(2).

  According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

  12.4 Mobility in soil

  The Koc of N-methylformamide is estimated as 7(SRC), using a log Kow of -0.97(1) and a regression-derived equation(2). According to a

  classification scheme(3), this estimated Koc value suggests that N-methylformamide is expected to have very high mobility in soil(SRC).

  12.5 Other adverse effects

  no data available

  13.Disposal considerations

  13.1 Disposal methods

  Product

  The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not

  contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

  Contaminated packaging

  Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it

  unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible

  packaging materials.

  14.Transport information

  14.1 UN Number

  ADR/RID: UN2924IMDG: UN2924IATA: UN2924

  14.2 UN Proper Shipping Name

  ADR/RID: FLAMMABLE LIQUID, CORROSIVE, N.O.S.

  IMDG: FLAMMABLE LIQUID, CORROSIVE, N.O.S.

  IATA: FLAMMABLE LIQUID, CORROSIVE, N.O.S.

  14.3 Transport hazard class(es)

  ADR/RID: 3IMDG: 3IATA: 3

  14.4 Packing group, if applicable

  ADR/RID: IIIMDG: IIIATA: II

  14.5 Environmental hazards

  ADR/RID: noIMDG: noIATA: no

  14.6 Special precautions for user

  no data available

  14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

  no data available

  15.Regulatory information

  15.1 Safety, health and environmental regulations specific for the product in question

  Chemical name Common names and synonyms CAS number EC number

  N-methylformamide N-methylformamide 123-39-7 none

  European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.

  EC Inventory Listed.

  United States Toxic Substances Control Act (TSCA) Inventory Listed.

  China Catalog of Hazardous chemicals 2015 Not Listed.

  New Zealand Inventory of Chemicals (NZIoC) Listed.

  Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.

  Vietnam National Chemical Inventory Listed.

  Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.

  16.Other information

  Information on revision

  Creation Date Aug 10, 2017

  Revision Date Aug 10, 2017

  Abbreviations and acronyms

  CAS: Chemical Abstracts Service

  ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road

  RID: Regulation concerning the International Carriage of Dangerous Goods by Rail

  IMDG: International Maritime Dangerous Goods

  IATA: International Air Transportation Association

  TWA: Time Weighted Average

  STEL: Short term exposure limit

  LC50: Lethal Concentration 50%

  LD50: Lethal Dose 50%

  EC50: Effective Concentration 50%

  References

  IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

  HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

  IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

  eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:

  http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

  CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

  ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

  ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

  Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

  ECHA - European Chemicals Agency, website: https://echa.europa.eu/

  Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this

  document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any

  guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.