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hydroquinone 123-31-9 SAFETY DATA SHEETS

2018.09.13 Category:Company profile Share  

  SAFETY DATA SHEETS

  According to Globally Harmonized System of Classification and Labelling of

  Chemicals (GHS) - Sixth revised edition

  Version: 1.0

  Creation Date: Aug 10, 2017

  Revision Date: Aug 10, 2017

  1.Identification

  1.1 GHS Product identifier

  Product name hydroquinone

  1.2 Other means of identification

  Product number-

  Other names 1,4-benzenediol

  1.3 Recommended use of the chemical and restrictions on use

  Identified

  uses

  For industry use only. Hydroquinone is used as a developing agent in black-and-white photography, lithography, and x-ray films. It is

  also used as an intermediate to produce antioxidants for rubber and food. It is added to a number of industrial monomers to inhibit

  polymerization during shipping, storage, and processing.

  Uses

  advised

  against

  no data available

  1.4 Supplier's details

  1.5 Emergency phone number

  Emergency phone number-

  Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

  2.Hazard identification

  2.1 Classification of the substance or mixture

  Acute toxicity - Oral, Category 4

  Serious eye damage, Category 1

  Skin sensitization, Category 1

  Germ cell mutagenicity, Category 2

  Carcinogenicity, Category 2

  Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

  2.2 GHS label elements, including precautionary statements

  Pictogram(s)

  Danger

  Signal word

  Danger

  Hazard statement(s)

  H302 Harmful if swallowed

  H318 Causes serious eye damage

  H317 May cause an allergic skin reaction

  H341 Suspected of causing genetic defects

  H351 Suspected of causing cancer

  H400 Very toxic to aquatic life

  Precautionary

  statement(s)

  Prevention

  P264 Wash ... thoroughly after handling.

  P270 Do not eat, drink or smoke when using this product.

  P280 Wear protective gloves/protective clothing/eye protection/face protection.

  P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

  P272 Contaminated work clothing should not be allowed out of the workplace.

  P201 Obtain special instructions before use.

  P202 Do not handle until all safety precautions have been read and understood.

  P273 Avoid release to the environment.

  Response

  P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

  P330 Rinse mouth.

  P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and

  easy to do. Continue rinsing.

  P310 Immediately call a POISON CENTER/doctor/…

  P302+P352 IF ON SKIN: Wash with plenty of water/...

  P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

  P321 Specific treatment (see ... on this label).

  P362+P364 Take off contaminated clothing and wash it before reuse.

  P308+P313 IF exposed or concerned: Get medical advice/ attention.

  P391 Collect spillage.

  Storage P405 Store locked up.

  Disposal P501 Dispose of contents/container to ...

  2.3 Other hazards which do not result in classification

  none

  3.Composition/information on ingredients

  3.1 Substances

  Chemical name Common names and synonyms CAS numberEC numberConcentration

  hydroquinone hydroquinone 123-31-9 none 100%

  4.First-aid measures

  4.1 Description of necessary first-aid measures

  General advice

  Consult a physician. Show this safety data sheet to the doctor in attendance.

  If inhaled

  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

  In case of skin contact

  Remove contaminated clothes. Rinse and then wash skin with water and soap.

  In case of eye contact

  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

  If swallowed

  Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

  4.2 Most important symptoms/effects, acute and delayed

  This material is very toxic; the probable oral lethal dose for humans is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 lb. person. It

  is irritating but not corrosive. Fatal human doses have ranged from 5-12 grams, but 300-500 mg have been ingested daily for 3-5 months without

  ill effects. Death is apparently initiated by respiratory failure or anoxia. (EPA, 1998)

  4.3 Indication of immediate medical attention and special treatment needed, if necessary

  /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration,

  preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush

  contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down

  position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical

  attention. /Aniline and related compounds/

  5.Fire-fighting measures

  5.1 Extinguishing media

  Suitable extinguishing media

  To fight fire, use water, carbon dioxide, dry chem ... .

  5.2 Specific hazards arising from the chemical

  Dust cloud may explode if ignited in an enclosed area. It can react with oxidizing materials and is rapidly oxidized in the presence of alkaline

  materials. Oxidizes in air. (EPA, 1998)

  5.3 Special protective actions for fire-fighters

  Wear self-contained breathing apparatus for firefighting if necessary.

  6.Accidental release measures

  6.1 Personal precautions, protective equipment and emergency procedures

  Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel

  to safe areas. Avoid breathing dust. For personal protection see section 8.

  6.2 Environmental precautions

  Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the

  environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local

  regulations.

  6.3 Methods and materials for containment and cleaning up

  Environmental Considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet

  to prevent dissolving in rain or fire fighting water. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk

  liquid with fly ash, cement powder, or commercial sorbents. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be

  sealed with an impermeable flexible membrane liner./

  7.Handling and storage

  7.1 Precautions for safe handling

  Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide

  appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

  7.2 Conditions for safe storage, including any incompatibilities

  Separated from strong bases and food and feedstuffs.Keep well closed and protected from light.

  8.Exposure controls/personal protection

  8.1 Control parameters

  Occupational Exposure limit values

  Recommended Exposure Limit: 15 Min Ceiling Value: 2 mg/cu m.

  Biological limit values

  no data available

  8.2 Appropriate engineering controls

  Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

  8.3 Individual protection measures, such as personal protective equipment (PPE)

  Eye/face protection

  Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government

  standards such as NIOSH (US) or EN 166(EU).

  Skin protection

  Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous

  substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without

  touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable

  laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive

  89/686/EEC and the standard EN 374 derived from it.

  Respiratory protection

  Wear dust mask when handling large quantities.

  Thermal hazards

  no data available

  9.Physical and chemical properties

  Physical state off-white powder or white needle-like crystals

  Colour White crystals

  Odour Odorless

  Melting point/ freezing point 2°C(lit.)

  Boiling point or initial boiling point and boiling range 285°C(lit.)

  Flammability Combustible Solid; dust cloud may explode if ignited in an enclosed area.Combustible.

  Lower and upper explosion limit / flammability limit no data available

  Flash point 165°C

  Auto-ignition temperature 498.89°C

  Decomposition temperature no data available

  pH no data available

  Kinematic viscosity no data available

  Solubility In water:70 g/L (20 oC)

  Partition coefficient n-octanol/water (log value) no data available

  Vapour pressure 1 mm Hg ( 132 °C)

  Density and/or relative density 1.332

  Relative vapour density 3.81 (vs air)

  Particle characteristics no data available

  10.Stability and reactivity

  10.1 Reactivity

  no data available

  10.2 Chemical stability

  Its solution becomes brown in air due to oxidation.

  10.3 Possibility of hazardous reactions

  Fire hazard: slight, when exposed to heat or flame; can react with oxidizing materials.Dust explosion possible if in powder or granular form, mixed

  with air.HYDROQUINONE is a slight explosion hazard when exposed to heat. Incompatible with strong oxidizing agents. Also incompatible with

  bases. It reacts with oxygen and sodium hydroxide. Reacts with ferric salts . Hot and/or concentrated NaOH can cause hydroquinone to

  decompose exothermically at elevated temperature. (NFPA Pub. 491M, 1975, 385)

  10.4 Conditions to avoid

  no data available

  10.5 Incompatible materials

  Strong oxidizers, alkalis.

  10.6 Hazardous decomposition products

  no data available

  11.Toxicological information

  Acute toxicity

  Oral: LD50 Rat oral 320 mg/kg

  Inhalation: no data available

  Dermal: no data available

  Skin corrosion/irritation

  no data available

  Serious eye damage/irritation

  no data available

  Respiratory or skin sensitization

  no data available

  Germ cell mutagenicity

  no data available

  Carcinogenicity

  Evaluation: There is inadequate evidence in humans for the carcinogenicity of hydroquinone. There is limited evidence in experimental animals for

  the carcinogenicity of hydroquinone. Overall evaluation: Hydroquinone is not classifiable as to its carcinogenicity to humans (Group 3).

  Reproductive toxicity

  No information is available on the reproductive or developmental effects of hydroquinone in humans. A slight reduction in maternal body weight

  gain, decreased fetal weight, increased resorption rate, and reduced fertility in males have been observed in rats orally exposed to hydroquinone

  via gavage or in the diet. Exposure of rabbits to hydroquinone via gavage produced negligible developmental alterations.

  STOT-single exposure

  no data available

  STOT-repeated exposure

  no data available

  Aspiration hazard

  no data available

  12.Ecological information

  12.1 Toxicity

  Toxicity to fish: LC50; Species: Danio rerio (Zebra danio) length 2.5 cm; Conditions: freshwater, static, 22°C, pH 7-7.8, hardness 150

  mg/L CaCO3; Concentration: <1000 ug/L for 24 hr

  Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea) age 6-24 hr; Conditions: freshwater, static,

  20°C, pH > or =7.0; Concentration: 320 ug/L for 24 hr (95% confidence interval: 270-380 ug/L); Effect: intoxication, immobilization

  /formulation

  Toxicity to algae: no data available

  Toxicity to microorganisms: no data available

  12.2 Persistence and degradability

  AEROBIC: Hydroquinone at a concentration of 0.05 mg/L underwent 7.5% removal in 5 days when inoculated with an activated sludge

  seed(1,2). Sewage sludge activated to phenol was found to oxidize hydroquinone(3,4). Pure culture oxidation of hydroquinone produced 1,4-

  benzoquinone, 2-hydroxy-1,4-benzoquinone and beta-ketoadipic acid(5). In a screening study using a sewage seed, hydroquinone had a 5 day

  theoretical BOD of 25.3%(6). Hydroquinone at an initial concentration of 200 mg/L COD underwent 54.2% removal (less than 120 hours) using a

  thickened adapted activated sludge under aerobic conditions(7). Activated sludges adapted to aniline, phenol or m-cresol were found to

  biodegrade hydroquinone under aerobic conditions(8). It was listed as undergoing rapid biodegradation in a commercial activated sludge unit

  under aerobic conditions(9).

  12.3 Bioaccumulative potential

  An estimated BCF of 3 was calculated in fish for hydroquinone(SRC), using a log Kow of 0.59(1) and a regression-derived equation(2).

  According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). A bioaccumulation

  factor of 40 was measured using Golden ide fish (Leuciscus idus melanotus) exposed for 3 days to 0.05 mg/L hydroquinone(4,5). Experimental

  24-hour bioaccumulation factors in alga were 40 and 65 for hydroquinone(4-6).

  12.4 Mobility in soil

  Using a structure estimation method based on molecular connectivity indices(1), the Koc of hydroquinone is estimated as 240(SRC). According to

  a classification scheme(2), this estimated Koc value suggests that hydroquinone is expected to have moderate mobility in soil. Hydroquinone can

  exhibit chemisorption to transition metal-containing particulate matter via reaction with the copper oxide/silca surfaces present(3).

  12.5 Other adverse effects

  no data available

  13.Disposal considerations

  13.1 Disposal methods

  Product

  The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not

  contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

  Contaminated packaging

  Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it

  unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible

  packaging materials.

  14.Transport information

  14.1 UN Number

  ADR/RID: UN3077IMDG: UN3077IATA: UN3077

  14.2 UN Proper Shipping Name

  ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

  IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

  IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

  14.3 Transport hazard class(es)

  ADR/RID: 9IMDG: 9IATA: 9

  14.4 Packing group, if applicable

  ADR/RID: IIIIMDG: IIIIATA: III

  14.5 Environmental hazards

  ADR/RID: yesIMDG: yesIATA: yes

  14.6 Special precautions for user

  no data available

  14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

  no data available

  15.Regulatory information

  15.1 Safety, health and environmental regulations specific for the product in question

  Chemical name Common names and synonyms CAS number EC number

  hydroquinone hydroquinone 123-31-9 none

  European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.

  EC Inventory Listed.

  United States Toxic Substances Control Act (TSCA) Inventory Listed.

  China Catalog of Hazardous chemicals 2015 Listed.

  New Zealand Inventory of Chemicals (NZIoC) Listed.

  Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.

  Vietnam National Chemical Inventory Listed.

  Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.

  16.Other information

  Information on revision

  Creation Date Aug 10, 2017

  Revision Date Aug 10, 2017

  Abbreviations and acronyms

  CAS: Chemical Abstracts Service

  ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road

  RID: Regulation concerning the International Carriage of Dangerous Goods by Rail

  IMDG: International Maritime Dangerous Goods

  IATA: International Air Transportation Association

  TWA: Time Weighted Average

  STEL: Short term exposure limit

  LC50: Lethal Concentration 50%

  LD50: Lethal Dose 50%

  EC50: Effective Concentration 50%

  References

  IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

  HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

  IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

  eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:

  http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

  CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

  ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

  ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

  Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

  ECHA - European Chemicals Agency, website: https://echa.europa.eu/

  Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this

  document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any

  guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product