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2,4,6-Collidine 108-75-8 SAFETY DATA SHEETS

2018.08.21 Category:Company profile Share  


  According to Globally Harmonized System of Classification and Labelling of

  Chemicals (GHS) - Sixth revised edition

  Version: 1.0

  Creation Date: Aug 12, 2017

  Revision Date: Aug 12, 2017


  1.1 GHS Product identifier

  Product name 2,4,6-Collidine

  1.2 Other means of identification

  Product number-

  Other names 2,4,6-TriMethylpyridine

  1.3 Recommended use of the chemical and restrictions on use

  Identified uses For industry use only. Food additives -> Flavoring Agents

  Uses advised againstno data available

  1.4 Supplier's details

  1.5 Emergency phone number

  Emergency phone number-

  Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

  2.Hazard identification

  2.1 Classification of the substance or mixture

  Flammable liquids, Category 3

  Acute toxicity - Oral, Category 4

  Acute toxicity - Dermal, Category 4

  Skin irritation, Category 2

  Eye irritation, Category 2

  Acute toxicity - Inhalation, Category 4

  Specific target organ toxicity – single exposure, Category 3

  2.2 GHS label elements, including precautionary statements


  Signal word Warning

  H226 Flammable liquid and vapour

  Hazard statement(s)

  H226 Flammable liquid and vapour

  H302 Harmful if swallowed

  H312 Harmful in contact with skin

  H315 Causes skin irritation

  H319 Causes serious eye irritation

  H332 Harmful if inhaled

  H335 May cause respiratory irritation




  P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

  P233 Keep container tightly closed.

  P240 Ground and bond container and receiving equipment.

  P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

  P242 Use non-sparking tools.

  P243 Take action to prevent static discharges.

  P280 Wear protective gloves/protective clothing/eye protection/face protection.

  P264 Wash ... thoroughly after handling.

  P270 Do not eat, drink or smoke when using this product.

  P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

  P271 Use only outdoors or in a well-ventilated area.


  P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or


  P370+P378 In case of fire: Use ... to extinguish.

  P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

  P330 Rinse mouth.

  P302+P352 IF ON SKIN: Wash with plenty of water/...

  P312 Call a POISON CENTER/doctor/…if you feel unwell.

  P321 Specific treatment (see ... on this label).

  P362+P364 Take off contaminated clothing and wash it before reuse.

  P332+P313 If skin irritation occurs: Get medical advice/attention.

  P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and

  easy to do. Continue rinsing.

  P337+P313 If eye irritation persists: Get medical advice/attention.

  P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.


  P403+P235 Store in a well-ventilated place. Keep cool.

  P403+P233 Store in a well-ventilated place. Keep container tightly closed.

  P405 Store locked up.

  Disposal P501 Dispose of contents/container to ...

  2.3 Other hazards which do not result in classification


  3.Composition/information on ingredients

  3.1 Substances

  Chemical name Common names and synonyms CAS numberEC numberConcentration

  2,4,6-Collidine 2,4,6-Collidine 108-75-8 none 100%

  4.First-aid measures

  4.1 Description of necessary first-aid measures

  General advice

  Consult a physician. Show this safety data sheet to the doctor in attendance.

  If inhaled

  If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

  In case of skin contact

  Wash off with soap and plenty of water. Consult a physician.

  In case of eye contact

  Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

  If swallowed

  Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  4.2 Most important symptoms/effects, acute and delayed

  Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: Inhalation or contact with material may irritate or burn skin and eyes. Fire

  may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may

  cause pollution. (ERG, 2016)

  4.3 Indication of immediate medical attention and special treatment needed, if necessary

  /SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if

  necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat

  if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... .

  Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag

  reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/

  5.Fire-fighting measures

  5.1 Extinguishing media

  Suitable extinguishing media

  Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: CAUTION: All these products have a very low flash point: Use of water

  spray when fighting fire may be inefficient. CAUTION: For mixtures containing alcohol or polar solvent, alcohol-resistant foam may be more

  effective. SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not use straight

  streams. Move containers from fire area if you can do it without risk. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from

  maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out.

  Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in

  fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)

  5.2 Specific hazards arising from the chemical

  Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or

  flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air.

  They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in

  sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or

  explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid

  vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved,

  refer to ERG Guide 169. (ERG, 2016)

  5.3 Special protective actions for fire-fighters

  Wear self-contained breathing apparatus for firefighting if necessary.

  6.Accidental release measures

  6.1 Personal precautions, protective equipment and emergency procedures

  Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel

  to safe areas. Avoid breathing dust. For personal protection see section 8.

  6.2 Environmental precautions

  Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

  6.3 Methods and materials for containment and cleaning up

  Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  7.Handling and storage

  7.1 Precautions for safe handling

  Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide

  appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

  7.2 Conditions for safe storage, including any incompatibilities

  Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  8.Exposure controls/personal protection

  8.1 Control parameters

  Occupational Exposure limit values

  no data available

  Biological limit values

  no data available

  8.2 Appropriate engineering controls

  Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

  8.3 Individual protection measures, such as personal protective equipment (PPE)

  Eye/face protection

  Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government

  standards such as NIOSH (US) or EN 166(EU).

  Skin protection

  Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous

  substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without

  touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable

  laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive

  89/686/EEC and the standard EN 374 derived from it.

  Respiratory protection

  Wear dust mask when handling large quantities.

  Thermal hazards

  no data available

  9.Physical and chemical properties

  Physical state Colorless liquid. Aromatic odor.

  Colour Colorless liquid

  Odour Aromatic odor

  Melting point/ freezing point -43oC

  Boiling point or initial boiling point and boiling range 171-172°C(lit.)

  Flammability no data available

  Lower and upper explosion limit / flammability limit no data available

  Flash point 55°C

  Auto-ignition temperature no data available

  Decomposition temperature no data available

  pH no data available

  Kinematic viscosity no data available

  Solubility In water:35 g/L (20 oC)

  Partition coefficient n-octanol/water (log value) log Kow = 1.88

  Vapour pressure 1.9mmHg at 25°C

  Density and/or relative density 0.914g/mLat 20°C

  Relative vapour density no data available

  Particle characteristics no data available

  10.Stability and reactivity

  10.1 Reactivity

  no data available

  10.2 Chemical stability

  Stable under recommended storage conditions.

  10.3 Possibility of hazardous reactions

  COLLIDINE neutralizes acids in exothermic reactions to form salts plus water. These acid-base reactions are exothermic. Incompatible with

  isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen

  in combination with strong reducing agents such as hydrides.

  10.4 Conditions to avoid

  no data available

  10.5 Incompatible materials

  no data available

  10.6 Hazardous decomposition products

  When heated to decomposition it emits toxic vapors of /nitrogen oxides/.

  11.Toxicological information

  Acute toxicity

  Oral: LD50 Rat oral 400 mg/kg

  Inhalation: no data available

  Dermal: no data available

  Skin corrosion/irritation

  no data available

  Serious eye damage/irritation

  no data available

  Respiratory or skin sensitization

  no data available

  Germ cell mutagenicity

  no data available


  no data available

  Reproductive toxicity

  no data available

  STOT-single exposure

  no data available

  STOT-repeated exposure

  no data available

  Aspiration hazard

  no data available

  12.Ecological information

  12.1 Toxicity

  Toxicity to fish: no data available

  Toxicity to daphnia and other aquatic invertebrates: no data available

  Toxicity to algae: no data available

  Toxicity to microorganisms: no data available

  12.2 Persistence and degradability

  AEROBIC: 2,4,6-Trimethylpyridine, present at 1 mM, degraded 100% in >97 days at pH 7 using a 0.5% garden soil suspension with glucose-

  yeast extract (20 ppm) and a screening test(1). Within 2 weeks, 100% transformation of 2,4,6-trimethylpyridine occurred in soil previously

  contaminated with pyridine contaminants(2).

  12.3 Bioaccumulative potential

  An estimated BCF of 6 was calculated for 2,4,6-trimethylpyridine(SRC), using a log Kow of 1.9(1) and a regression-derived equation(2).

  According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

  12.4 Mobility in soil

  The Koc of 2,4,6-trimethylpyridine is estimated as 250(SRC), using a log Kow of 1.9(1) and a regression-derived equation(2). According to a

  classification scheme(3), this estimated Koc value suggests that 2,4,6-collidine is expected to have moderate mobility in soil(SRC). The pKa of

  2,4,6-trimethylpyridine is 7.4(4), indicating that this compound will partially exist in the protonated form in the environment and cations generally

  adsorb to organic carbon and clay more strongly than their neutral counterparts(5).

  12.5 Other adverse effects

  no data available

  13.Disposal considerations

  13.1 Disposal methods


  The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not

  contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

  Contaminated packaging

  Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it

  unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible

  packaging materials.

  14.Transport information

  14.1 UN Number

  ADR/RID: UN1992IMDG: UN1992IATA: UN1992

  14.2 UN Proper Shipping Name




  14.3 Transport hazard class(es)

  ADR/RID: 6.1IMDG: 6.1IATA: 6.1

  14.4 Packing group, if applicable


  14.5 Environmental hazards

  ADR/RID: noIMDG: noIATA: no

  14.6 Special precautions for user

  no data available

  14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

  no data available

  15.Regulatory information

  15.1 Safety, health and environmental regulations specific for the product in question

  Chemical name Common names and synonyms CAS number EC number

  2,4,6-Collidine 2,4,6-Collidine 108-75-8 none

  European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.

  EC Inventory Listed.

  United States Toxic Substances Control Act (TSCA) Inventory Listed.

  China Catalog of Hazardous chemicals 2015 Not Listed.

  New Zealand Inventory of Chemicals (NZIoC) Listed.

  Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.

  Vietnam National Chemical Inventory Not Listed.

  Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.

  16.Other information

  Information on revision

  Creation Date Aug 12, 2017

  Revision Date Aug 12, 2017

  Abbreviations and acronyms

  CAS: Chemical Abstracts Service

  ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road

  RID: Regulation concerning the International Carriage of Dangerous Goods by Rail

  IMDG: International Maritime Dangerous Goods

  IATA: International Air Transportation Association

  TWA: Time Weighted Average

  STEL: Short term exposure limit

  LC50: Lethal Concentration 50%

  LD50: Lethal Dose 50%

  EC50: Effective Concentration 50%


  IPCS - The International Chemical Safety Cards (ICSC), website:

  HSDB - Hazardous Substances Data Bank, website:

  IARC - International Agency for Research on Cancer, website:

  eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:

  CAMEO Chemicals, website:

  ChemIDplus, website:

  ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:

  Germany GESTIS-database on hazard substance, website:

  ECHA - European Chemicals Agency, website:

  Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this

  document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any

  guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.